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In vitro results show that FÓRMIDA selectively attacks pathogenic E. coli, offering a precise alternative to broad-spectrum antibiotics.
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As antibiotic resistance rises, this study reinforces the need for targeted, sustainable solutions like phage therapy to protect animal health and food systems.
In poultry production, not all E. coli are harmful — but the ones that are, can be devastating.
A new in vitro laboratory study published in the Poultry Science Journal by PhageLab’s scientific team presents FÓRMIDA, a tailor-made bacteriophage cocktail designed to selectively target Avian Pathogenic Escherichia coli (APEC) — one of the leading bacterial causes of mortality in broiler chickens.
As antibiotic resistance continues to rise, this study reinforces a growing consensus in veterinary health: the future of bacterial control must be precise, sustainable, and science-based.
Between 2013 and 2017, colibacillosis — a disease caused by APEC — led to the condemnation of more than 8 million chickens in Brazil alone. Meanwhile, overuse of antibiotics has helped resistant strains spread, creating a critical need for new tools that protect poultry health without fueling antimicrobial resistance.
A Laboratory Study in Specificity
In this study, researchers analyzed 142 E. coli isolates collected from broiler farms in Brazil. Using the genomic classification tool APECtyper, the strains were divided into four pathotypes — including High-Risk APEC, the most urgent target.
PhageLab scientists then screened 66 bacteriophages, selecting 8 with complementary host ranges. These were assembled into four cocktail candidates and tested in vitro.
One stood out: FÓRMIDA (cocktail AC-01)
Here’s a simple (and fun) way to learn more about the study:
Towards More Intelligent Solutions
By linking pathogen classification with phage selection, this study offers a replicable model for how the industry can move beyond one-size-fits-all treatments.
Instead of eliminating bacteria indiscriminately, FÓRMIDA targets the real threats — and leaves the rest alone.
“This study shows that specificity matters,” said Rodrigo Norambuena, Scientist at PhageLab and co-author of the paper. “When we truly understand what we’re fighting, we can build solutions that are smarter, safer, and more sustainable.”
Highlights
- Developed using APECtyper genomic classification.
- Effective against multidrug-resistant APEC from commercial broiler farms.
- High specificity reduces disruption to beneficial bacteria.
- Validated in vitro and designed for field-ready stability.
